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Welcome to Bingchen Yu group at Georgia State University,
where Chemistry dances with Biology
Organic Chemistry
Medicinal Chemistry
Biochemistry
Chemical Biology

Bingchen Yu lab at GSU is committed to advancing the study of signal transduction and medicine by focusing on the complex area of protein-biomolecule interactions. Proteins interact with proteins, carbohydrates, nucleic acids, and lipids. These interactions govern every aspect of life. Deciphering these interactions can contribute to the understanding of the fundamental aspects of life and open up diverse opportunities for therapeutic intervention. Additionally, the modulation of protein-biomolecule interactions such as protein-protein interactions (PPIs) represents a promising frontier in drug discovery, as it allows the targeting of "undruggable" proteins with flat surfaces.

 

Our lab is dedicated to developing innovative chemical tools that can covalently capture the transient and reversible protein-biomolecule interactions. To achieve this, we employ a multi-disciplinary approach that integrates organic synthesis, molecular biology, and protein engineering. By combining these techniques, we aim to gain a better understanding of the roles that protein-biomolecule interactions play in disease progression, and ultimately facilitate the discovery of new drugs that target protein-biomolecule interactions.

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Interested in joining our Lab?

Our research group is currently seeking highly motivated graduate students at both M.S. and Ph.D. levels. We offer tuition waivers and monthly stipends to support our students. Working with us, graduate students will have the opportunity to develop strong skills in organic synthesis, medicinal chemistry, biochemistry, protein engineering, and molecular biology. We encourage applicants with B.S. or M.S. degrees in organic chemistry, pharmaceutical science, biochemistry, or molecular biology to apply. Additionally, we welcome undergraduate students to join our lab and gain valuable research experience.

We are also hiring a postdoctoral researcher with a background in organic chemistry, medicinal chemistry, or molecular biology. If you are interested, please contact us at byu8@gsu.edu.

Academic collaboration


Our lab is open to collaboration with the broader scientific community in the fields of biology and chemistry. We have extensive experience in designing chemical tools to investigate protein-biomolecule interactions, and we are eager to collaborate with talented scientists to further our understanding of PPIs and identify the molecular targets of proteins of interest.
 

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