Dr. Bingchen Yu graduated from Shandong University in China in 2014 with a B.S. degree in Pharmaceutical Science. He then received his Ph.D. degree in Chemistry in Georgia State University (GSU). His Ph.D. work in Prof. Binghe Wang’s lab in the Department of Chemistry at GSU focused on prodrug development for hydrogen sulfide and persulfide species. Notably, he uncovered that persulfide exhibited elevated pharmacological activities and better safety profiles than hydrogen sulfide, which contributed to a paradigm shift from hydrogen sulfide to persulfide. He also led a project on the discovery of antibiotic adjuvants, which can enhance the potency of existing antibiotics against drug-resistant bacteria. After receiving his Ph.D. degree, he took a postdoctoral position with Prof. Binghe Wang to continue working on this exciting project and advance product commercialization.

In 2020, He joined Prof. Lei Wang’s lab as a postdoctoral associate in the Department of Pharmaceutical Chemistry at the University of California, San Francisco (UCSF) to expand his research interests. His post-doc research focused on developing covalent protein drugs, which can form a covalent and irreversible bond with their targets via genetic code expansion and a proximity-enabled reactive therapeutic (PERx) mechanism. He developed covalent nanobodies that effectively neutralized SARS-CoV-2 with increased potency and covalent sugar binders for cancer immune therapy.

In 2023, he joined the Department of Chemistry at GSU at an assistant professor. His training and expertise include organic chemistry, drug discovery, and chemical biology. He has long-term research interests in building chemical tools to probe signal transduction and develop medicine.

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In his leisure time, he enjoys traveling (especially road trip), snow skiing, playing badminton, and hiking with family and friends. He is also an All-Pro Dad by training and love to spend time with his daughter above all else.